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Certolizumab is a Fab fragment of a humanized monoclonal antibody against tumor necrosis factor-alpha (TNF-alpha). Differing from the other TNF-alpha inhibitors due to the absence of Fc fragment and pegylation, it binds to both the soluble and transmembrane forms of TNF-alpha, creating a strong TNF-alpha blockage. Previously approved for psoriatic arthritis, certolizumab received another approval from FDA in 2018 for the treatment of moderate to severe chronic plaque psoriasis that does not respond to conventional systemic treatments or for which these treatments are contraindicated. Administered via subcutaneous injections, certolizumab also has a low-dose option for patients weighing less than 90 kg. Certolizumab is considered a safe biological drug that can be preferred during pregnancy and lactation.Copyright © 2022 by Turkish Society of Dermatology and Venereology.
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This 654-page tome might be the most comprehensive look to date at how various governments - nearly 40 in all - have sought to respond to the COVID-19 pandemic during its first 10 months, from December 2019 to September 2020. The COVID-19 pandemic has been associated with an immense growth in scientific literature, with more than 700,000 scientists publishing well over 300,000 items related to COVID-19 by the summer of 2021. Time and time again, from place to place, the COVID-19 pandemic demonstrated that extensive public health expertise from an advisory agency meant relatively little if such counsel was discounted by politicians and public health agencies lacking their own decision-making powers. [Extracted from the article] Copyright of World Medical & Health Policy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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Aim: The aim of this research is to analyze the pediatric COVID-19 literature published in Turkey and to guide future research. Material(s) and Method(s): Between 11.03.2010 and 11.12.2022, the Web of Science (WoS) All Databases collection was searched for publications related to COVID-19 and pediatric patients. The keywords used during this search were coronavirus-19, COVID-19, SARS-CoV-2, novel coronavirus, 2019-nCoV, pandemic, and/or pediatric, pediatric, children, child. After this search, the selected publications were scanned one by one to determine whether they were suitable for the present study. Authors, organizations, journals, document types, distribution of publications by years (months), most used keywords were obtained from the Web of Science (WoS) All Databases collection. Descriptive analyzes were made from all these obtained data. Result(s): The number of COVID-19 publications originating from Turkey in the field of pediatrics was determined as 375. 48.2% of all publications were published in 2022. These 375 publications were published in 167 different journals. In these publications, the most active author, journal and organization were Yasemin Ozsurekci, Turkish Archives of Pediatrics and University of Health Sciences, Turkey, respectively. The most commonly used keywords were ''child, patient, pandemic, SARS-CoV and vaccine. The most active document types were research articles (295 (78.6%)), editorial materials (15 (4.0%)), letters (43 (11.5%)) and review articles (22 (5.9%)). Discussion(s): We analyzed all articles about COVID-19 from Turkey in the field of pediatrics published so far in the WoS Databases collection. It is obvious that a large literature has emerged in our country on pediatric patients, although not as much as in adults. The long-term adverse effects of the pandemic on pediatric practice and especially on children will need to be evaluated in more detail in future research.Copyright © 2023, Derman Medical Publishing. All rights reserved.
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As important combat platforms, large warships have the characteristics of compact internal space and dense personnel. Once infectious diseases occur, they are very easy to spread. Therefore, it is very important to select suitable forecasting models for infectious diseases in this environment. This paper introduces 4 classic dynamics models of infectious diseases, summarizes various kinds of compartmental models and their key characteristics, and discusses several common practical simulation requirements, helping relevant health personnel to cope with the challenges in health and epidemic prevention such as the prevention and control of coronavirus disease 2019.Copyright © 2022, Second Military Medical University Press. All rights reserved.
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Background: The COVID-19 pandemic catalyzed innovation in infection control measures, including widespread deployment of digital contact tracing systems. However, these technologies were not well understood by the general public and were complex for the public health community to implement, hampering adoption. Objective(s): To provide an overview of existing digital contact tracing systems, creating a framework for understanding design elements that impact their effectiveness as public health tools and offering a rubric for decision-makers to evaluate different systems for selection and implementation. Method(s): Scientific literature and publicly available information from relevant health authorities and other stakeholders was reviewed. Information was synthesized to develop a conceptual framework explaining how key design elements impact effectiveness of digital contact tracing systems and highlighting opportunities for future improvement. Result(s): A range of digital contact tracing interventions were deployed by governments worldwide and several professional sports leagues. Key design elements of the systems include: (1) data architecture (i.e., centralized versus decentralized systems, impacting privacy guarantees and data availability);(2) proximity detection technology (e.g., type of device signaling);(3) alert logic and timing (e.g., time- and distance-based criteria affecting sensitivity and specificity of alerts;real-time proximity alerts and/or bidirectional contact tracing, determining scope of infection prevention);(4) population (eligibility and availability);and (5) the structural and public health context of intervention (e.g., availability and timeliness of testing). Several systems demonstrated effectiveness in preventing transmission during COVID-19, though numerous limitations have also been documented in the literature. Conclusion(s): Digital contact tracing systems have the potential to mitigate the economic and public health impact of future infectious disease outbreaks, reducing community transmission and detecting potential cases earlier in the disease course. Lessons learned from solutions deployed during the COVID-19 pandemic provide an opportunity to improve multiple aspects of these systems, enhancing preparedness for future outbreaks.Copyright © 2023
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In order to determine the trend of studies on the factors that generate the consumption of paid video streaming platforms during the COVID-19 pandemic, a systematic review of scientific literature was conducted. To search for the information, the Scopus database and the Concytec repository, Alicia, were consulted. The keywords "streaming”, "platform”, "media”, "COVID-19”, "Netflix”, "video” and "pandemic” were used. Sources were located in three languages. The data analysis allowed dividing the information into five categories: background on the positioning of streaming platforms, audience behaviour, consumption drivers, cases related to Netflix and platforms in times of confinement. It is concluded that during the pandemic, people mutated their mode of digital consumption, becoming more dependent, which has been capitalised on by streaming platforms that, taking advantage of habits, adaptability, and consumption trends, and responding with innovation, have increased users, in a distribution of the sector in which Netflix, thanks to its own strategies, is the leader. These reviewed factors move a consumer marketplace uphill, creating loyalty among previous audiences and tempting new ones, which could even overcome the pandemic period. © 2023, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
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In 2020, the European Association of Preventive Cardiology proposed the important role of exercise-based cardiac rehabilitation (CR) in the management of cardiovascular and metabolic diseases, and called on everyone to take action. This paper discusses the current status and future perspective of individualized active exercise-based CR for coronary artery disease (CAD) from 4 dimensions, including the basic and clinical research progress of exercise-based CR for CAD, evidence on the benefits of exercise-based CR on ameliorating CAD complications, the exercise-based CR guidelines in different countries, and the implementation of exercise-based CR under coronavirus disease 2019 pandemic, so as to provide reference for research and clinical work.Copyright © 2022, Second Military Medical University Press. All rights reserved.
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Beyond the classic categorical classifications of eating disorders (ED) (i.e., anorexia nervosa, bulimia, etc.), recent scientific writings, particularly in the context of COVID-19, demonstrate the importance of considering dysfunctional eating attitudes and behaviours (DEAB). Indeed, this continuum of well-being and dietary health ranging from a so-called 'functional' state (absence of DEAB) to a dysfunctional state in dietary health (proven presence of an ED) responds to this holistic and integrated perspective of health. Among existing interventions, the use of the natural environment appears to be a promising prevention and intervention modality for individuals living with DEAB. However, no recent scientific literature conceptualizes the use of the natural environment on the DEAB continuum. The objective of the communication is therefore to present the progress of a research project and to offer a conceptual, methodological, and experimental insight into the use of the context of nature applied to DEAB in a population engaged in a clinical program (eLoriCorps). Quasi-experimental research with mixed design aims for a secondary use of data from the research unit Loricorps' database (BDL) and a research/intervention using nature for people with DEAB. Those studies include individuals aged of at least 18 years old who present DEAB of various severities. The expected results of this study aim to highlight the promising avenues of this non-drug intervention within a clinical program to provide reliable indicators to the scientific community and thus contribute to the development of best practices in the management of this disorder.
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INTRODUCTION: To carry out a retrospective bibliometric analysis of articles, published since the beginning of the pandemic, which addressed the topic of physical exercise and COVID-19, in order to provide a reference of origin for research on the topic. EVIDENCE ACQUISITION: This is a bibliometric study, which addressed the production / dissemination, through information recorded in the PubMed database, about physical exercise and COVID-19, published since the beginning of the pandemic. EVIDENCE SYNTHESIS: 111 publications in total were retrieved from PubMed in the first round of research and 93 publications were identified after reviewing the study titles and s. Eligibility was assessed for these 93 publications throughout the text and 76 were entered after removing duplicates and irrelevant records. According to Bradford's Law, we identified 76 publications in 53 journals from seven different countries. The countries of the journals that published the most were the United States (20, 37.7%) and the United Kingdom (15, 28.3%). The journals that most published on the subject were: European Journal of Physical and Rehabilitation Medicine, Obesity, Encephale and Progress in Cardiovascular Diseases, each with 03 studies. According to Lotka's Law, the most productive authors: Lavie CJ Smith I, with 4 articles published. When evaluating the word frequencies by Zipf's Law, it was observed that 16 words had at least 10 occurrences, with the words Covid-19, Exercise and Pandemic with 80, 39 and 38 occurrences respectively. CONCLUSION(S): According to our analysis, this research provides a current scenario of how studies related to physical exercise and COVID-19 are going on in the world, serving as a reference for researchers on this topic.Copyright © 2020 EDIZIONI MINERVA MEDICA.
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Zhang's broad argument that capitalism, urbanization, agricultural industrialization, and the fetishization of biomedical innovation may instigate - rather than quell - global disease outbreaks is persuasive. Finally, in "Persistence", Zhang tackles the geopolitical tensions around COVID-19 and illustrates how each outbreak in the ongoing pandemic reinforces framings of epidemics as "natural" disasters, blinding us to the ecomodernist roots of infectious disease. In her opening "Prelude", Zhang reveals how state-making, science and technology, and global capitalism are entangled in contemporary China, often to the detriment of public health. [Extracted from the article] Copyright of Journal of Asian Studies is the property of Duke University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)